Focus Areas

Surgery of the thyroid and parathyroid glands

Conventional (open) and minimally invasive adrenal surgery

Minimally invasive and conventional (open) surgery for tumors and other diseases of the stomach, small intestine and large intestine

Minimally invasive and conventional surgery for gallstones or gallbladder inflammation

Conventional and minimally invasive surgery for inguinal hernias (hernias), abdominal wall hernias and diaphragmatic hernias

Minimally invasive reflux surgery

Diagnostic laparoscopy (scopy of the abdominal cavity) for the purpose of taking biopsies (tissue samples) in the case of unclear diseases in the abdomen

Minimally invasive adhesiolysis for passage disorders due to adhesions in the abdomen after abdominal surgery or illness Implantation of a port-a-cath (permanent access to the venous system) for chemotherapy lymph node biopsies

Since 2022, Prof. R. Droeser has been carrying out some of his minimally invasive procedures with robot assistance (da Vinci Xi system, Intuitive)

Medical Education & Academic Career

Academic activities

• Development and management of a research group in the field of endocrine and neuroendocrine research at the University Center for Gastrointestinal and Liver Diseases Clarunis Basel
• Over 70 English-language publications in specialist journals (topics: hernia surgery, endocrine surgery, development of thyroid tissue from stem cell lines, quality of life after colorectal surgery, tumor immunology in solid tumors, microbiome in colon carcinoma)
• Lectures on various visceral surgical topics, practical examination courses and clinical rounds for medical students at the University of Basel
• Management of a research project on the importance of interleukin-22, which was funded by the Swiss Cancer League
• Supervision of surgical doctoral and master theses
• Lectureship at the University of Basel: Lecture on adrenal tumors/incidentaloma (1st master's year)
• Instructor & exam expert, Objective Structured Clinical Evaluation (OSCE). 3rd and 4th year course, Medical Faculty University of Basel

Committee memberships

Membership in Associations

• Association of Swiss Doctors (FMH)
• Swiss Society of Surgery (SGC)
• Swiss Society for Visceral Surgery (SGVC)
• Endocrine Surgery Working Group (AGEC)
• Swiss Neuroendocrine Tumor Registry (SwissNET)
• European Neuroendocrine Tumor Society (ENETS)
• Ärztegesellschaft des Kantons Zürich (AGZ)
• Interdigest: Ärzte-Netzwerk von Spezialisten auf dem Gebiet der Gastroenterologie, Viszeralchirurgie und Onkologie

Publications

These publications are available on Pubmed.

Original Research Papers

First author

Droeser RA, Frey DM, Oertli D, Kopelman D, Baas-Vrancken Peeters MJ, Giuliano AE, Dalberg K, Kallam R, Nordmann A. Volume-controlled vs no/short-term drainage after axillary lymph node dissection in breast cancer surgery: a meta-analysis. Breast (IF: 2.1, obstetrics & gynecology, rank 23/70), 2009 Apr;18(2):109-14.

Frey DM*, Droeser RA*, Viehl CT, Zlobec I, Lugli A, Zingg U, Oertli D, Kettelhack C, Terracciano L, Tornillo L. High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. Int J Cancer (IF: 4.9, oncology, rank 32/185), 2010 Jun;126(11):2635-43.

*equally contributed

Droeser RA, Zlobec I, Kilic E, Guth U, Heberer M, Spagnoli GC, Oertli D, Tapia C. Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+ tumor infiltrating lymphocytes in ductal and lobular breast cancers. BMC Cancer (IF: 3.3, oncology, rank 73/197), 2012 Apr;12(1):134.

Droeser RA, Jeanmonod P, Schuld J, Moussavian MR, Schilling MK, Kollmar O. Octreotide Prophylaxis Is Not Beneficial for Biochemical Activity and Clinical Severity of Postoperative Pancreatic Fistula after Pancreatic Surgery. Dig Surg (IF: 1.7, surgery, rank 79/204), 2013 Jan 31;29(6):484-491.

Droeser RA, Hirt Ch, Eppenberger-Castori S, Zlobec I, Viehl CT, Frey DM, Nebiker Ch, Rosso R, Zuber M, Amicarella F, Iezzi G, Sconocchia G, Heberer M, Lugli A, Tornillo L, Oertli D, Lugli A, Terrracciano L and Spagnoli GC. High myeloperoxidase positive cell infiltration in colorectal cancer is an independent favorable prognostic factor. PlosOne (IF: 3.5, multidisciplinary sciences, rank 8/55), 2013 May;8(5):e64814.

Droeser RA, Hirt H, Viehl CT, Frey DM, Huber X, Zlobec I, Eppenberger-Castori S, Tzankov A, Rosso R, Zuber M, Muraro MG, Amicarella F, Heberer M, Iezzi G, Lugli A, Terracciano L, Sconocchia G, Oertli D, Spagnoli GC and Tornillo L. Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. Eur J Cancer (IF: 4.8, oncology, rank 41/203), 2013 Jun;49(9):2233-42.

Droeser RA, Obermann EC, Wolf AM, Wallner S, Wolf D, Tzankov A. Negligible Nuclear FoxP3 Expression in Breast Cancer Epithelial Cells Compared to FoxP3 Positive T Cells. Clin Breast Cancer (IF: 2.6, oncology, rank 106/203), 2013 Aug;13(4):264-70.

Droeser RA, Güth U, Eppenberger-Castori S, Stadlmann S, Hirt Ch, Terracciano L and Singer G. High IL-17 positive tumor immune cell infiltration is indicative for chemosensitivity of ovarian carcinoma. J Cancer Res Clin Oncol (IF: 3.0, oncology, rank 81/203), 2013 Aug; 139(8):1295-302.

Droeser RA, Dell-Kuster S, Kurmann A, Rosenthal R, Zuber M, Metzger J, Oertli D, Hamel CT and Frey DM. Long-term follow up of a randomized controlled trial of Lichtenstein’s operation versus mesh plug repair for inguinal hernia. Ann Surg (IF: 8.3, surgery, rank 1/198), 2014 May 259(5):966-72.

Droeser RA, Mechera R, Däster S, Weixler B, Kraljević M, Delko T, Güth U, Stadlmann S, Terracciano L, Singer G. MPO density in primary cancer biopsies of ovarian carcinoma enhances the indicative value of IL-17 for chemosensitivity. BMC Cancer (IF: 3.3, oncology, rank 93/217), 2016 Aug 17;16:639.

Droeser RA, Ottosson J, Muth A, Hultin H, Lindwall-Åhlander K, Bergenfelz A, Almquist M. Hypoparathyroidism after total thyroidectomy in patients with previous gastric bypass. Langenbecks Arch Surg (IF: 2.2, surgery, rank 74/196), 2017 Mar;402(2):273-280.

Dell-Kuster S*, Droeser RA*, Schäfer J, Gloy V, Ewald H, Schandelmaier S, Hemkens LG, Bucher HC, Young J, Rosenthal R. Systematic review and simulation study of ignoring clustered data in surgical trials. Br J Surg (IF: 5.9, surgery, rank 7/197), 2018 Feb;105(3):182-191.

*equally contributed

 

Last author

Däster S, Eppenberger-Castori S, Hirt C, Zlobec I, Delko T, Nebiker CA, Soysal SD, Amicarella F, Iezzi G, Sconocchia G, Heberer M, Lugli A, Spagnoli GC, Kettelhack C, Terracciano L, Oertli D, von Holzen U, Tornillo L and Droeser RA. High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer. Disease Markers (IF: 1.6, pathology, rank 52/75), 2014;2014:792183.

Däster S, Eppenberger-Castori S, Hirt C, Soysal SD, Delko T, Nebiker CA, Weixler B, Amicarella F, Iezzi G, Governa V, Padovan E, Mele V, Sconocchia G, Heberer M, Terracciano L, Kettelhack C, Oertli D, Spagnoli GC, von Holzen U, TornilloL, Droeser RA. Absence of myeloperoxidase and CD8 positive cells in colorectal cancer infiltrates identifies patients with severe prognosis. Oncoimmunology (IF: 6.3, oncology, rank 21/210), 2015 May 29;4(12):e1050574.

Weixler B, Cremonesi E, Sorge R, Muraro MG, Delko T, Nebiker CA, Däster S, Governa V, Amicarella F, Soysal SD, Kettelhack C, von Holzen UW, Eppenberger-Castori S, Spagnoli GC, Oertli D, Iezzi G, Terracciano L, Tornillo L, Sconocchia G, Droeser RA. OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer. Oncotarget (IF: 5.0, oncology, rank 36/213), 2015 Nov10;6(35):37588-99.

Sterlacci W, Fiegl M, Droeser RA*, Tzankov A*. Expression of PD-L1 Identifies a Subgroup of More Aggressive Non-Small Cell Carcinomas of the Lung. Pathobiology (IF: 1.7, pathology, rank 49/79), 2016;83(5):267-75.

*shared last authorship

Ramser M, Eichelberger S, Däster S, Weixler B, Kraljević M, Mechera R, Tampakis A, Delko T, Güth U, Stadlmann S, Terracciano L, Droeser RA*, Singer G*. High OX40 expression in recurrent ovarian carcinoma is indicative for response to repeated chemotherapy. BMC Cancer (IF: 3.3, oncology, rank 93/217), 2018 Apr 16;18(1):425.

*shared last authorship

Haak F, Obrecht I, Tosti N, Weixler B, Mechera R, Däster S, von Strauss M, Delko T, Spagnoli GC, Terracciano L, Sconocchia G, von Flüe M, Kraljević M, Droeser RA. Tumor Infiltration by OX40+ Cells Enhances the Prognostic Significance of CD16+ Cell Infiltration in Colorectal Cancer. Cancer Control (IF: 2.0, oncology, rank 182/230), 2020 Jan-Dec;27(1).

Tosti N, Cremonesi E, Governa V, Basso C, Kancherla V, Coto-Llerena M, Amicarella F, Weixler B, Däster S, Sconocchia G, Majno PE, Christoforidis D, Tornillo L, Terracciano L, Ng CKY, Piscuoglio S, von Flüe M, Spagnoli G, Eppenberger-Castori S, Iezzi G, Droeser RA. Infiltration by interleukin-22 producing T cells promotes neutrophil recruitment and predicts favorable clinical outcome in human colorectal cancer. Cancer Immunol Res (IF: 8.7, oncology, rank 23/230), 2020 Nov;8(11):1452-1462.

Facile I, Galli R, Dinter P, Rosenberg R, Von Flüe M, Steinemann DC, Posabella A, Droeser RA. Short- and long-term outcomes for primary anastomosis versus Hartmann's procedure in Hinchey III and IV diverticulitis: a multivariate logistic regression analysis of risk factors. Langenbecks Arch Surg (IF: 2.2, surgery, rank 83/210), 2021 Feb;406(1):121-129.

Lalos A, Tülek A, Tosti N, Mechera A, Wilhelm A, Soysal S, Däster S, Kancherla V, Weixler B, Spagnoli GC, Eppenberger-Castori S, Terracciano L, Piscuoglio S, von Flüe M, Posabella A, Droeser R. Prognostic significance of CD8+ T-Cells density in Stage III colorectal cancer depends on SDF-1 expression. Scientific Reports (IF: 4.0, multidisciplinary science, rank 17/71), 2021 Jan 12;11(1):775

Tampakis A, Weixler B, Rast S, Tampaki EC, Cremonesi E, Kancherla V, Tosti N, Kettelhack C, Ng CKY, Delko T, Soysal SD, von Holzen U, Felekouras E, Nikiteas N, Bolli M, Tornillo L, Terracciano L, Eppenberger-Castori S, Spagnoli GC, Piscuoglio S, von Flüe M, Däster S, Droeser RA. Nestin and CD34 expression in colorectal cancer predicts improved overall survival. Acta Oncologica (IF: 3.7, oncology, rank 99/244), 2021 Jun 60(6):727-734.

Lalos A, Neri O, Ercan C, Wilhelm A, Staubli S, Posabella A, Weixler B, Terracciano L, Piscuoglio S, Stadlmann S, Spagnoli GC, Droeser RA*, Singer G*. High Density of CD16+ Tumor-Infiltrating Immune Cells in Recurrent Ovarian Cancer Is Associated with Enhanced Responsiveness to Chemotherapy and Prolonged Overall Survival. Cancers (Basel) (IF: 6.6, oncology, rank 51/242), 2021 Nov 18;13(22):5783.

*shared last authorship

Review Articles and Comments

Hirt C, Eppenberger-Castori S, Sconocchia G, Iezzi G, Tornillo L, Terracciano L, Spagnoli GC, Droeser RA. Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis. Oncoimmunology (IF: 6.3, oncology, rank 21/210), 2013 Oct;2(10):e25990

Delko T, Hoffmann H, Kraljević M, Droeser RA, Rothwell L, Oertli D, Zingg U. Erratum to: Intraoperative Patterns of Gastric Microperfusion During Laparoscopic Sleeve Gastrectomy. Obes Surg. (IF: 3.9, surgery, rank 18/196), 2017 Jun;27(6):1641.

Tampaki EC, Tampakis A, Droeser R, Patsouris E, Kouraklis G. Cabozantinib and Vandetanib in medullary thyroid carcinoma: mitochondrial function and its potential as a therapeutic target towards novel strategies to design anti-CSCs drugs. Cancer Biol Ther (IF: 3.3, oncology, rank 92/217), 2018;19(10):847-849.

Posabella A, Alber AB, Undeutsch HJ, Droeser RA, Hollenberg AN, Ikonomou L, Kotton DN. Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine. Front Endocrinol (Lausanne) (IF: 3.6, endocrinology & metabolism, rank 54/143), 2021 Apr 20;12:666565.

Droeser RA, Iezzi G. IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer. J Cell Immunol (IF: NA, rank NA), 2021;3(2):118-121.

Dissertations

2014-20

PhD student: Nadia Tosti

Prognostic and functional significance of interleukin-22 in colorectal cancer. Direction: Prof. L. Terracciano and Prof. R. Droeser Speaker: Prof. A. Odermatt Co-speaker: Prof. M. Kruithof de Julio

2017

Doctoral candidate: Fabienne Renetseder

Prognostic role of CXCR4 and pCXCR4 in colorectal cancer.

2020

Doctoral candidate: Fabian Haak

Prognostic role of combined CD16 and OX40 expression in CRC.

Doctoral candidate: Alberto Posabella

High density of CD66b in primary high-grade ovarian cancer independently predicts response to chemotherapy.

2021

Doctoral candidate: Alexandros Lalos

Prognostic role of combined SDF-1 and CD8 expression in CRC.

Doctoral candidate: Ivan Facile

Short- and long-term outcomes for primary anastomosis versus Hartmann's procedure in Hinchey III and IV diverticulitis: a multivariate logistic regression analysis of risk factors.

2022

Doctoral candidate: Fabio Walther

Predictive role of CXCR4 and pCXCR4 for chemosensitivity in ovarian cancer. Management: Prof. R. Droeser